Rabbit eye irritation (Low volume procedure) of GO955.01 [foam formulation containing 0.3% Lauramine Oxide] and GO932.01 [liquid formulation containing 0.3% Lauramine Oxide]. The ratings indicate the relative level of concern posed by exposure to the ingredients in this product - not the product itself - compared to other product formulations. 089-0116. Acute oral toxicity (LD50) [of 0.3% Lauramine Oxide] in rats.” Test no. Low Concern . Stearamine Oxide applied to rabbit skin at 5% did not cause irritation. *, Industrial Biology Laboratories, Inc. (1963) Unpublished data submitted by CTFA. PB85-122661. *, Hazelton Laboratories America, Inc. (1990) Submission of unpublished data by CTFA. Four Sprague-Dawley rats were given intraperitoneal injections of 22 mg (methyl-14C)lauramine oxide kg (specific activity 1.3 mCi/g). *, International Research and Development Corporation. Potentially significant hazards to health or the environment or poor ingredient disclosure. The international Organisation for Economoic Co-operation and Development reported that amine oxides are not genotoxic. *, Springborn Life Sciences, Inc. (1987) Submission of unpublished data by CTFA. For more information view the SAGE Journals Article Sharing page. Lauramine Oxide is an Amine N-oxide, an active component primarily found in shampoo, bubble bath and hand soap thanks to its foam building properties . It is one of the most frequently-used surfactants of this type. Cancer . It provides high foaming and thickening properties and is stable at most pH ranges, including, stability in peroxide and hypochlorite solutions. *, Estrin NF , Crosley PA , Haynes CR , eds. Dodecylamine, N,n-dimethyl-, N-oxide (6ci,8ci), 108. Thermeidics Company, Mass. The international Organisation for Economoic Co-operation and Development reported that amine oxides are not carcinogenic. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 231-45 (1994). (1-Dodecyl-14C)lauramine oxide (10 mg with 100 uCi of 14C) was applied to the skin of two humans to study cutaneous absorption and metabolism of lauramine oxide. Can reduce the irritation of … (1986) Submission of unpublished data by CTFA. (1990a) Submission of unpublished data by CTFA. (. *, Leberco Testing Inc. (1985) Unpublished data submitted by CTFA. Cosmetic Ingredient Review; Final Report on the Safety Assessment of Lauramine Oxide and Stearamine Oxide; Journal of American College of Toxicology 13 (3): 234 (1994). (. The international Organisation for Economoic Co-operation and Development reported that amine oxides do not cause dermal sensitization. Members of _ can log in with their society credentials below. SIDS Initial Assessment Profile for SIAM 22 April 18-21, 2006. 2006. NTIS No. Please check you selected the correct society from the list and entered the user name and password you use to log in to your society website. Good ingredient disclosure. Martha Stewart Clean Carpet Stain Remover, Planet Delicate Laundry Wash, Hypo-Allergenic, Babyganics Floor Cleaner Concentrate, Fragrance Free, biokleen Natural Dish Liquid, Citrus Essence, Puracy Natural Laundry Detergent, Free & Clear, Earth Friendly Products ECOS Dishmate Dish Soap, Free & Clear, Earth Friendly Products ECOS Dishmate Dish Soap, Lavender, Total Home Earth Essentials Liquid Dish Soap, Eucalyptus Lemon, Dapple Baby Laundry Detergent Strips, Fragrance-Free, Total Home Earth Essentials Liquid Dish Soap, Fragrance Free. 1-dodecanamine, N,n-dimethyl-, N-oxide, 40. 3029.1426.*. Approximately 75% of the total radioactivity was excreted within 24 hr of oral administration. Journal of the American College of Toxicology, Urinary bladder neoplasms in Syrian hamsters after administration of N-nitroso-N-methyl-N-dodecylamine, Methods for detecting carcinogens and mutagens with the Sa/monella/mammalian-microsome mutagenicity test, The relationship between mutagenicity and carcinogenicity of some nitrosamines, Mutagenicity of amine drugs and their products of nitrosation, Comparison of the carcinogenic effects of five nitrosamines in guinea pigs, Amine nitrosation and nitrosation by gaseous nitrogen dioxide, International Agency for Research on Cancer, Amine oxides.