FDA wants to remind you of the benefits of using approved drugs in your clinic. Good Luck. However she HATES it. Fun times! (480) 899-7738 I just want to make sure I am doing the best thing for my baby. “My experie… You can break up Proin into quarters and give her a small bit 3-4X daily. If you have any questions regarding your pet’s incontinence, contact your veterinarian to schedule an appointment. “Studies have shown that up to 20 percent of spayed dogs leak urine when resting or sleeping,” Dr. Nichol said. I researched this and talked to a number of people so far and I would be very grateful to anyone who could solve this problem for me, since I have to give him this for the rest of his life. Estrogens increase the resting muscle tone of the urethra in females and can be used to treat female dogs with urinary incontinence due to estrogen depletion. No offense, but proin is one of the cheaper meds. One of our loyal clients recently asked… “Hey Dr. Tenney: The goal of drug treatment is to increase the urethral tone and continence. The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely. That is 50 cents a day. We have tried incurin. Estrogen therapy may also be considered for dogs who do not tolerate phenylpropanolamine. An official website of the United States government, : I use a pill crusher or just crush it with a spoon when I can’t locate my crusher. June 3rd she had a grand mal seizure. Frequently the dogs are not aware that they are leaking urine. Sometimes, the agency’s post-approval monitoring uncovers safety and effectiveness issues that were unknown at the time of approval; The manufacturing process to ensure quality and consistency are maintained from batch to batch; The drug’s labeling to make sure the information remains truthful, complete, and not misleading; and. As a pharmacy, we’re unable to recommend any prescription drugs and urge you to talk with your dog’s veterinarian. and which one would you recommend for my dog? Please respond with answers for us and any other information you can provide. Veterinarians know urinary incontinence or involuntary urine leakage is a common problem encountered in dogs. Physical examination and blood and urine tests are usually normal in these pets. PROIN and PROIN ER are the only FDA-approved animal drugs that contain phenylpropanolamine as the active ingredient. Here are links to additional information about Proin and Incurin. Diethylstilbestrol is no longer made by a drug manufacturer and must be obtained through a compounding pharmacy like VetRxDirect. No offence taken. Dr Tenney. You should be aware of several potential causes to this problem. It was terrible as we were looking for an underlying cause. Please someone help me !!! My dog has been struck with this condition as well as a longtime friend of mines dog, unfortunately most publications usually speak of primarily of female pets. If you can get Proin online or at one of the Big Box stores and it is the identical product, not short dated (where the expiration date is nearly due or past due) go for it. We take it out by 4 (2 day supply) and let it thaw overnight in the fridge. In very rare cases vaginal bleeding and hair loss can be seen. She only eats once a day. Human Warnings: Not for human use. If it is a side effect, it should be listed as such. As long as the drug company markets the animal drug, the agency continues to monitor: FDA’s Center for Veterinary Medicine (CVM) is committed to promoting and protecting animal health by ensuring that safe and effective drugs are available for animals. In most cases, one to two doses per week are given thereafter. There’s so many side effects to Incurin some being very scary. The initial dose rate of Incurin is 1 tablet per dog per day. She is a doberman, btw. She was in rescue and spayed at 10 weeks, before we got her. Like all prescription drugs, DES has potential side effects. Or if you could find another way to give it that he won’t be exposed to the taste during ungestion. PROIN ER is approved for once daily administration and available in 18, 38, 74, and 145 mg strength tablets (NADA 141-517). Phenylpropanolamine may be prescribed alone or in combination with estrogen therapy. We throw away blankets and dog beds daily, and we buy huge remnants of carpet from home depot and throw them away and replace them every 6 months. I gave it once to my Lab and she almost stroked out – panting, and snarling, pacing for hours. Her heart was pounding even while sleeping….not going to use it any longer. Thanks in advance. The company must make sure that the labeling contains all necessary information to use the drug safely and effectively and includes the risks associated with the drug. Caution: Glaucoma, prostatic hypertrophy, hyperthyroidism, diabetes mellitus, cardiovascular disorders, or hypertension. Can you please tell me the difference between Proin and Incurin? We tried to give her breakfast and dinner, but she rarely ever ate breakfast until dinner time. THANKS. Very expensive. He seems to find it extremely offencive. Treatment is recommended to be started at one tablet per day for 7 to 14 days. We searched web for side effects of this medication and didn’t find seizures as one of them. In a margin of safety study, phenylpropanolamine hydrochloride (PPA) was administered to dogs twice daily at 1X, 3X or 5X the recommended dose (2 mg/kg) for 182 days. My suggestion would be to speak with your veterinarian and see about have the active ingredient, phenylpropanolamine, formulated at a compounding pharmacy. I feel so bad for her because she was house broken at 9 weeks and never went in the house..she is so humiliated when it happens. Manufactured by Pegasus Laboratories, Inc., PROIN and PROIN ER are also prescription drugs. Adverse Effects: Restlessness, irritability, hypertension, & anorexia. We searched web for side effects of this medication and didn’t find seizures as one if them. Nothing. Is it? She has TERRIBLE skin problems, almost unbearable during the summer (in FL it’s always summer). It’s a traumatic event for all involved when I do give it to her. Remember that there are a few alternatives to Proin. My vet told me to contact a compounding pharmacy which I did ,they stated they made that in six different flavors I’ve tried two so far, he hates all equally so far which has made it very difficult, this has made it much less likely to stay consistent and giving him this dose which is necessary every day at this point. Below are the most common side effects of Proin (or Phenylpropanolamine) I had a similar experience I am taking my dog off of it. But if you buy your prescriptions from us, you have us to advise you and stand behind our products. How much you spending on laundering the soiled bedding and washing your dog? We did DES at a holistic vet and acupuncture, nothing has helped. Wash your hands with soap and water after administration to avoid exposure to the drug. She usually gets about half in her mouth cuz she shakes her head. It ought to include a six month supply of proin for the price. Oasis Animal Hospital is proud to serve the following areas: Vision and Mission of Oasis Animal Hospital. I am just going to get the diapers now and hope that it can make her more comfortable, and maybe she can lay in a bed for more than a day before it is destroyed. You should consult your veterinarian if you notice any side effects and keep all follow-up appointments. We here to answer any questions you have. Easier for the dog to take and digest. Chris please don’t let her live out her days peeing herself. I feel like this may make her more comfortable, to not have to constantly lay in urine, and smell like it. Manufactured by Intervet, Inc., INCURIN is a prescription drug available in 1 mg strength tablets [New Animal Drug Application (NADA) 141-325]. This study demonstrated the safety of phenylpropanolamine administered to dogs at 2, 6 and 10 mg/kg twice daily for 6 months. Possible side effects have included signs of estrus (in heat), swollen vulva/teats and nausea. Has anyone else experienced this? Incurin is made by Merck Animal Health and is available in a 1 mg estriol (sometimes referred to as oestriol) tablet. Worked. I crush half a pill, mix with enough water and beef bullion to draw into a 5cc syringe and push it into her mouth. This has proven to be both safe (if given at the prescribed doses) and effective (In an FDA approved 28 day clinical trial PROIN reduced mean urinary accidents per week in female dogs by 82%. We have tried incurin. Proin, PPA for Urinary Incontinence in Spayed Dogs. My dog will not take the tablet. The alpha-adrenergic agonist, phenylpropanolamine, also known as PPA (Proin, Propalin), is a commonly prescribed treatment option for urethral incontinence. Incurin should not be used in animals less than 1 year old. This drug is really awful.We took her off of it and no more bad side effects. I just paid out the nose for it at my vet : 90 for 180 50mg tabs. Proin – a chewable formulation with the active compound of phenylpropanolamine hydrochloride (PPA). Click to share on Facebook (Opens in new window), Click to share on Twitter (Opens in new window), Click to share on Pinterest (Opens in new window), Incurin: New FDA Approved Drug for Urinary Incontinence, phenylpropanolamine, also known as PPA (Proin, Propalin), estrogen product called diethylstilbestrol, also referred to as DES, estrogen treatment option named Incurin (estriol). Will you please include “new posts” by email. Her teeth are big. It was terrible as we were looking for an underlying cause. Took her outside to “walk it off” after mistakenly thinking some food would “dilute” the affects. Our precious dog was on Incurin for an extended time; one 1mg tab once a day – no 7 to 14 day treatment – given to her to take regularly 1mg tab once daily with no further instructions. She acts like she’s being punished after I get one down and we’re doing this twice a day. The pills softens and our dog will eat it right down – only way we have found to get a hard pill down her. She is now not just leaking, but full on, full bladder like in a fast drip, until she is soaking EVERYTHING. My vet first prescribed the tablets which my friend’s dog ate like treats unfortunately that was not my experience with mine. The pet can urinate normally, but they leak urine while resting. Urinary incontinence (involuntary urine leakage) can be caused by different medical conditions. For as much as she loves us unconditionally we should spoil her, not torture. Bailey is only a year old, and her occasional bouts of incontinence did not start until after she was spayed. I found the same thing online for $60. Did your dog start to fall after taking it a while. The drug’s safety and effectiveness. In the second part of the clinical field study (180 days), PROIN achieved 98.1% owner satisfaction for the control of urinary incontinence.) This condition will usually start months to years after being spayed. It is Proin for some urinary incontinence. She can be sleeping, or sitting on your lap and she suddenly piddles. The company’s marketing communications related to the drug to make sure the information is truthful and not misleading. She threw up immediately (stupid – like giving dog food immediately after playing) and re-ate before I could get to it. My dog is a 9 year old Dachshund male and he ate the first one and ever since he literally runs and hides from me if he sees me coming. Questions regarding the timing and age of onset of the incontinence will help your pet’s veterinarian determine if the condition may have existed prior to or shortly after birth, shortly after being spayed, or if another reason is causing the incontinence. I am out of my mind. (???) I can’t believe my dog is the only dog that hates this medication. Incurin is not for use in male dogs and should not be used during pregnancy or lactation. Give them Proin. Sounds pretty hard. My dog is doing great on Proin. FDA rigorously evaluates an animal drug before approving it. Please refer to Animal Drugs @ FDA for more information about INCURIN, PROIN, and PROIN ER.