What are the possible side effects that may occur in my horse during Equioxx Equioxx provides consistent pain relief associated with equine OA (also called degenerative joint disease) for 24 hours with just one daily dose. Equioxx is an NSAID and requires a prescription from your veterinarian. Had him in wedge pad with shoes on front, and gave Equioxx … Based upon radiolabel studies, the majority of label is eliminated in the urine as the decyclopropylmethylated metabolite. NSAIDs may inhibit the prostaglandins that maintain normal homeostatic function. It's available in a chewable tablet and a paste for easy administration. Horses treated with Equioxx Oral Paste showed improvement in veterinarian-assessed lameness, pain on manipulation, range of motion, and joint swelling that was comparable to the active control. To deliver the correct dose, round your horse's body weight up to the nearest 50 lb increment (if the body weight is an exact 50 lb increment, do not round up). A Client Information Sheet should be provided to the person treating the horse. To deliver the correct dose, round your horse's body weight up to the nearest 50 lb increment (if the body weight is an exact 50 lb increment, do not round up). Brief excursions up to 104°F (40°C) are permitted. Consider appropriate washout times when switching from one NSAID to another NSAID or corticosteroid. Sensitivity to drug-associated adverse events varies with the individual patient. One male 5X horse with an elevated GGT value on Day 42 was noted to have tubulointerstitial nephropathy at the time of necropsy. The recommended dosage of Equioxx Paste is 0.045 mg/lb of body weight once daily for up to 14 days. Consult your veterinarian if your horse receives more than the prescribed. You should give a Client Information Sheet to the person treating the horse and advise them of the potential for adverse reactions and the clinical signs associated with NSAID intolerance. We'll verify your prescription and ship your order! for Horses (Polysulfated Glycosaminoglycan), Itrafungol Oral Solution for Cats (52 ml). You should read this information before you start giving your horse Equioxx paste and review it each time your prescription is refilled. Decreased activity or exercise (reluctance to stand, walk, trot or run, or difficulty in performing these activities). Papillary necrosis was seen in the 2.5X and 12.5X groups. Nearly every show organization has their own rules and regulations about the use of NSAIDs during competition - so be sure to check with the governing body of an event before using any medication. In another target animal safety study, firocoxib was administered orally to healthy adult horses (three females, two male castrates and one male per group) at 0, 0.25 mg/kg, 0.75 mg/kg and 1.25 mg/kg (2.5, 7.5 and 12.5X the recommended dose of 0.1 mg/kg) for 92 days. Equioxx Paste comes in an easy-to-use oral syringe with graduated markings that will treat 250 lbs of body weight. What kind of results can I expect when my horse is on Equioxx for OA? The following adverse reactions were observed. Dose linearity exists from 1×-2× of 0.1 mg/kg/day. Serious adverse reactions associated with this drug class can occur without warning and, in rare situations, result in death. Administration of firocoxib at 0.1, 0.3 and 0.5 mg/kg body weight was associated with delayed healing of pre-existing oral (lip, tongue, gingival) ulcers. The safe use of Equioxx in horses less than 1 year in age, horses used for breeding, or in pregnant or lactating mares has not been evaluated. Osteoarthritis (OA) is a painful condition caused by progressive "wear and tear" of cartilage and other parts of the joints that may result in the following changes or signs in your horse: Equioxx should be given according to your veterinarian's instructions. Appropriate laboratory tests should be conducted to establish hematological and serum biochemical baseline data before and periodically during administration of any NSAID. In target animal safety studies, toxicity was seen at the recommended dose when the duration of treatment exceeded 30 days. Always provide the Client Information Sheet with the prescription. Simparica (sarolaner) Chewables Tablets for Dogs, Senergy (selamectin) Topical Parasiticide for Dogs & Cats, Seresto Flea & Tick Collar for Cats & Dogs, Advantage II Flea Control for Cats and Kittens, Nutramax Dasuquin Joint Supplement for Dogs & Cats, Banamine Paste - SINGLE Syringe 1500mg (30 gm) (Manufacturer may vary), FluMeglumine 50mg/ml Injectable 100ml (Manufacturer may vary), Optimmune Ophthalmic Ointment for Dogs 3.5 gm, Vetmedin (Pimobendan) Chewable Tablets for Dogs, Adequan i.m. Furthermore, Equioxx is the only NSAID approved for use up to 14 successive days by these two groups. If you liked this blog, please subscribe below, and share it with … There was a dose-dependent increase in the incidence of oral ulcers and erosions. The recommended dosage of Equioxx Paste is 0.045 mg/lb administered orally once daily for up to 14 days. Gross and microscopic lesions of the kidneys consistent with tubulointerstitial nephropathy were seen in all treated groups. Any side effects from taking Equioxx or other NSAIDs, such as aspirin or phenylbutazone. Tubulointerstitial nephropathy occurred in one 3× female, two 3× male horses, and the 5× female horse discussed above with the prolonged BMBT. The concomitant use of protein-bound drugs with Equioxx hasn't been studied in horses. When administered as a 0.045 mg/lb (0.1 mg/kg) dose in oral paste to adult horses with normal access to roughage, feed, and water, the absolute bioavailability of firocoxib from Equioxx paste is approximately 79%. Avoid giving your horse other anti-inflammatory drugs, such as NSAIDs or corticosteroids. If you have any questions or concerns about Equioxx or osteoarthritis pain, talk with your veterinarian. Eqioxx is helping me have a bit more time pain free with my boy, 1 tablet by mouth once daily for up to 14 days or as directed by your veterinarian, Give dose corresponding with your horse's weight once daily for up to 14 days, or as directed by your veterinarian, loc_en_US, sid_prod12146, prod, sort_[SortEntry(order=SUBMISSION_TIME, direction=DESCENDING)], bvseo_sdk, dw_cartridge, 18.2.0, p_sdk_3.2.0, loc_en_US, sid_prod12146, prod, sort_[SortEntry(order=LAST_APPROVED_ANSWER_SUBMISSION_TIME, direction=DESCENDING)], Controls pain and inflammation associated with osteoarthritis, Easy-to-administer chewable tablet or paste. Equioxx requires a prescription from your veterinarian. Horses were assessed for lameness, pain on manipulation, range of motion, joint swelling, and overall clinical improvement in a non-inferiority evaluation of Equioxx Oral Paste compared to an active control. In addition, several 12.5× horses had elevated liver enzymes (GGT, SDH, AST and ALT). The recommended dosage of Equioxx Tablets is one 57 mg tablet administered orally to horses weighing 800-1,300 lbs, once daily for up to 14 days. Tell your veterinarian about all medications you have given your horse in the past and any medications you are planning to give with Equioxx Oral Paste. What are the possible side effects that may occur in my horse during Equioxx, We comply with the HONcode standard for trustworthy health information -, Information for Owner or Person Treating Horse. Gastric ulcers of the margo plicatus and glandular area were more prevalent in the 2.5× and 7.5× groups, but not seen in the 12.5× group. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Prove in both field and laboratory trials to be safe at the recommended dose. With products that aren't meant to be used once a day, this may result in a roller-coaster effect of pain and pain relief. Equioxx is not for use in horses intended for human food consumption. However, in some animals, up to 12 hours may be needed before significant plasma concentrations are observed. Equioxx requires a prescription from your veterinarian. Concurrent administration of potentially nephrotoxic drugs should be carefully approached or avoided. Tell your veterinarian if your pet has ever had kidney disease, liver disease, or a gastrointestinal ulcer. One syringe can treat a horse up to 1,250 lbs. Just one convenient, daily dose lasts up to 24 hours and can help improve your horse's mobility. To deliver the correct dose, round the horse's body weight up to the nearest 50 pound increment (if the body weight is an exact 50 pound increment, do not round up). The terminal elimination half-life (T½) in plasma averages 30-40 hours after IV or oral paste dosing. Sores, scabs, redness, or rubbing of the facial skin, particularly around the mouth. A target animal safety study was conducted to assess the safety of Equioxx Injection followed by Equioxx Oral Paste in the horse. Slide the knurled ring along the plunger shaft so that the side nearest the barrel is at the appropriate 50 lb weight notch. Stiffness or decreased movement of joints. In addition, the incidence of oral ulcers was higher in all treated groups as compared to the control group. Rotate the plunger ring ¼ turn to lock it in place and ensure it is locked. Thank you for your question. So much easier than mixing butte. One 2.5X horse had increased urine GGT and urine protein levels which was due to renal hemorrhage and nephropathy. Just one convenient, daily dose lasts up to 24 hours and can … Equioxx is an NSAID and requires a prescription from your veterinarian. ®Equioxx is a registered trademark of Merial. Thirty-two clinically healthy adult horses received Equioxx Injection intravenously once daily for five days at doses of either 0 mg/kg (control group); 0.09 mg/kg (1X); 0.27 mg/kg (3X); or 0.45 mg/kg (5X the recommended dose). Since many NSAIDs possess the potential to produce gastrointestinal ulcerations and/or gastrointestinal perforation, concomitant use of Equioxx Tablets with other anti-inflammatory drugs, such as NSAIDs or corticosteroids, should be avoided. If an overdose is suspected, contact your veterinarian immediately. Gross and microscopic lesions of the kidneys consistent with tubulointerstitial nephropathy were seen in all treated groups. The safe use of Equioxx Oral Paste in horses less than one year in age, horses used for breeding, or in pregnant or lactating mares has not been evaluated. For ease of administration, EQUIOXX … You will only be charged when the order ships out. One horse from the control group and two horses from the 5X group had injection site swellings during treatment. Equioxx® **, *Clinical relevance has not been determined. There were treatment-related adverse events in all treated groups. Talk to your veterinarian if you do not understand any of this information or you want to know more about Equioxx. Drug compatibility should be monitored in patients requiring adjunctive therapy. Relative bioavailability of the two formulations was determined based on the analysis of plasma drug concentration in 30 horses at specific intervals during a two period crossover study with firocoxib oral paste and a firocoxib tablet. Temporarily Out of Stock - Order now, ships when back in stock. Other medical problems or allergies that your horse has now, or has had in the past. Such anti-prostaglandin effects may result in clinically significant disease in patients with underlying or pre-existing disease that has not been previously diagnosed.